High-performance nanoscale forms of biologically active and
medical substances
New “Amphidon” nanocarriers based on a series of original
amphiphilic polymers allow for production of high-performance forms
of medical and bio-active substances for use in medicine, beauty
industry, agriculture and biotechnology.
 The
new products use polymer nanoparticles as containers that can be
loaded with medical and bio-active substances and target-delivered
to the nidus of infection. Gradual and controlled discharge of the
active agent from the nanoparticles during the period of several
hours or even days make it possible to replace an entire course of
drug administration with a one-time delivery of the medical
substance to the infected area.
We have developed a simple and original technology for producing
nanocontainers based on synthetic polymers that have been long and
successfully used in medicine and pharmacology as blood substitutes,
etc. This approach guarantees higher safety of new drugs while at
the same time lowering their production cost compared to that of
currently developed analogues and thus making them highly
commercially viable.
The nanoscale capsules created by us can be loaded with bioactive
and medical substances that will be target-delivered and discharged
in the human body. The capsules have a comprehensive range of
properties that can be used as a basis for developing
high-performance solutions for diagnosis and treatment:
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- Average particle size from 20 to 300 nm;
- Close spread of particles by size;
- Spherical form;
- High load capacity (up to 80 %);
- Low toxicity;
- High compatibility with blood components;
- No interference with blood viscosity parameters;
- Biocompatibility;
- Good resistance during long storage periods;
- High mechanical and chemical resistance;
- Low cost and ease of production.
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Inserting bioactive and medical substances into nanoparticles
based on our amphiphilic polymers makes it possible to:
- Ensure solubility in water of
non-soluble or poorly soluble drugs (i.e. to make it
possible to deliver them using injection or by other
means);
- Ensure prolonged and controlled
discharge of the active agent;
- Lower toxicity and other side
effects of the drug;
- Ensure targeted delivery of the
drug to the nidus of infection by loading the
polymer with additional functional groups and
linking them with marker groups and molecules;
- Overcome protective barriers of
the body and guarantee the acquisition of the drug
by the cells of reticuloendothelian system;
- Decrease therapeutic doses of the
active agent while simultaneously increasing their
efficacy;
- Produce additional
immunostimulating effect on the body provided by the
polymer carrier’s own activity;
- Provide a high loading capability
for drug insertion (up to 80 %), making the
production profitable;
- Lower the body’s resistance to
the drug.
The importance of nanoscale delivery systems for pharmaceutical
industry:
- Research and development of new delivery systems
and of drug forms based on such systems is
considerably cheaper than research and development
of new active molecules;
- Decreasing the volume of drug in the medical
device while increasing its efficacy lowers the cost
of its production;
- Original delivery systems will increase the
commercial potential of the drug by differentiating
it from the analogues;
- New nanoparticle delivery systems may give fresh
impetus to using old, well-known drugs («resurrection»
of the drug);
- Polymer nanoscale form will allow to use
advanced drugs that were of limited use before due
to their poor solubility in aqueous environments.
It has been proven so far that the following drugs can be
inserted into the nanoparticles of our design:
- Anti-inflammatory – Indometacin and Dyclofenac;
- Antineoplastic – Doxorubicin, Angiostatin,
Cysplatin;
- Anti-tuberculosis – Rhyphampicin;
- Antimycotic – Nistatin, Amphotericin Â;
- Hepatoprotective – Silimarin;
- Bioactive proteins – BBI proteinase inhibitor,
IX blood factor.
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Amphotericin B – poorly soluble antimycotic antibiotic, located on
the surface and walls of the bubble (Figure A).
Comparison (Figure B): an equal quantity of Amphotericin B is
inserted inside polymer nanoparticles, a hydrocompatible form of
antibiotic is obtained. |
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Effect of different drug delivery forms of Angiostatin
antineoplastic on the growth of cancer tumor in laboratory mice. |
Our product is on the frontline of research in the development of
modern pharmaceutical industry and can lead to creation of an entire
range of innovative high-performance solutions for diagnosis and
treatment that do not have any direct analogues and are highly
competitive, commercially viable and possessing a definitive
investment appeal for application in pharmaceutics, biotechnology,
cosmetics and agriculture.
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